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John I. Glendinning
Associate Professor
Altschul 1105
(212) 854-4749
jglendinning (at) barnard.edu
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Research Interests
I study the physiological mechanisms that control feeding in animals. Most of my projects focus on the contribution of taste to feeding, but I have recently begun to explore the effects of learning and chemosensory feedback from the gut. Some of my current questions include: 1) how are food-related signals coded by the peripheral and central taste system, 2) how does taste input interact with other feeding-related inputs (e.g., positive feedback from the gut) to stimulate or inhibit feeding, 3) how do genetic manipulations of the taste system alter feeding responses of animals, and 4) how does the taste system help wild animals feed in an adaptive manner—i.e., consume nutritious foods and avoid toxic ones?
I have examined these questions in insects ( Manduca sexta caterpillars) and mammals (mice). I include both taxa in my research program because they provide a comparative perspective, and thereby offer insight into how phylogenetically unrelated animals solve common physiological problems.
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Representative recent publications: (Barnard students in bold)
Spector AC, Glendinning JI (2009) Linking peripheral taste processes to behavior. Current Opinion in Neurobiology 19: 370-377
Glendinning JI, Foley C , Loncar I , Rai M (2009) Induced preference for host plant chemicals in the tobacco hornworm: contribution of olfaction and taste. Journal of Comparative Physiology A 195: 591-601
Youngentob SL, Glendinning JI (2009) Fetal ethanol exposure increases ethanol intake by making it smell and taste better. Proceedings of the National Academy of Sciences USA 106(13): 5359-64
Zukerman S, Glendinning JI, Margolskee RF, Sclafani A (2009) T1R3 taste receptor is critical for sucrose but not Polycose taste. American Journal of Physiology 296: R866–R876
Glendinning JI, Feld N , Goodman L , Bayor R (2008) Orosensory attributes of oil influence daily intake of low, but not high concentrations of oil in mice. Physiology & Behavior 95: 476-483.
Glendinning JI, Yiin Y-M, Ackroff K, Sclafani A (2008) Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents. Physiology and Behavior 93: 757-765.
Glendinning JI (2008) Insect gustatory systems. In: Basbaum AI, Kaneko A, Shepherd GM, Westheimer G (eds) The Senses: A Comprehensive Reference, Volume 4, Olfaction and taste, Firestein S, Beauchamp GK. San Diego: Academic Press. p 75-95.
Glendinning JI, Jerud A , Weinberg A (2007) The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta . The Journal of Experimental Biology 210: 3054-3067
Glendinning JI (2007) How do predators cope with chemically defended foods? The Biological Bulletin 213: 252-266
Sclafani A, Zukerman S, Glendinning JI, Margolskee RF (2007) Fat and carbohydrate preferences in mice: the contribution of a-gustducin and Trpm5 taste signaling proteins. American Journal of Physiology 293: R1504–R1513.
Inoue M, Glendinning JI, Theodorides ML , Harkness S , Li X, Bosak N, Beauchamp GK, Bachmanov AA (2007) Polymorphisms in the Tas1r3 taste receptor gene alter taste responses to sweeteners: evidence from 129.B6- Tas1r3 congenic mice . Physiological Genomics 32(1): 82-94
Damak S, Rong M, Yasumatsu K, Kokrashvilli Z, Pérex CA, Shigemura N, Yoshida R, Mosinger B, Glendinning JI, Ninomiya Y, Margolskee RF (2006) Trpm5 null mice respond to bitter, sweet and umami compounds. Chemical Senses 31: 253-264.
Glendinning JI, Davis A , Rai M (2006) Temporal coding mediates discrimination of “bitter” taste stimuli by an insect (2006) The Journal of Neuroscience 26(35): 8900-8908
Glendinning JI, Bloom LD , Onishi M , Zheng KH , Damak S, Margolskee RF, Spector AC (2005) Contribution of a-gustducin to taste-guided licking responses of mice (2005) Chemical Senses 30(4): 299-316
Glendinning JI, Chyou S , Lin I, Onishi M , Patel P , Young MJ , Zheng KH (2005) Initial licking responses of mice to sweeteners: effects of Tas1r3 polymorphisms. Chemical Senses 30(7): 601-614
Sclafani A, Glendinning JI (2005) Sugar and fat conditioned flavor preferences in C57BL/6 and 129 mice: oral and post-oral interactions. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 289(3): R712-720
Sclafani A, Glendinning JI (2003) Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion. Physiology and Behavior 79: 783–788
Glendinning JI, Davis A, Ramaswamy S (2002) Contribution of different taste cells and signaling pathways to the discrimination of ‘bitter' taste stimuli by an insect. The Journal of Neuroscience 22(16): 7281-7287 |
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